CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells.
CADM1 is a major receptor for the adhesion of mast cells (MCs) to fibroblasts, human airway smooth muscle cells (HASMCs) and neurons.It also regulates E-cadherin and alpha6beta4 integrin in other cell types.Here we investigated a role for CADM1 in MC adhesion to both cells and extracellular matrix (ECM).Downregulation of CADM1 in the human MC line